March 10, 2021
Researchers from Tel Aviv University, the Sagol Center for Hyperbaric Medicine and Research, and the Shamir Medical Center conducted a study in which they concluded that Hyperbaric Oxygen Therapy (HBOT) increases telomere length and decreases immunosenescence in isolated blood cells, delaying the aging process. The article is published in Aging magazine.
Aging is characterized by the progressive loss of physiological integrity and results in impaired function, susceptibility to disease, and death. This biological deterioration is an important risk factor for cancer, cardiovascular diseases, diabetes, and Alzheimer's disease, among others. At the cellular level, there are two keys to the aging process: telomere length shortening and cellular senescence.
To study the effects of Hyperbaric Therapy on these two factors, a group of researchers led by Shai Efrati and Amir Hadanny treated 35 healthy people with an average age of 64 years. The patients received daily sessions of Hyperbaric Oxygen Therapy. It was concluded that repeated daily sessions of Hyperbaric Chamber Therapy can increase telomere length by more than 20% in an aging population. B cells have the most surprising change. Hyperbaric Oxygenation also decreases the number of senescent cells by 10-37%. T helper senescent cells are the most affected.
In a statement released by the Sagol Center for Medicine and Research, Efrati said that "understanding telomere shortening is the Holy Grail of aging biology."
Hadanny highlighted the importance of lengthening telomeres in just three months: "With this study, we open the door to new research on the cellular impact of Hyperbaric Oxygen Therapy to reverse the aging process."
In conclusion, the study indicates that HBOT can induce senolytic effects, including the significant increase in telomere length and the elimination of senescent cells in aging populations.
Hyperbaric Oxygen Therapy is a non-invasive medical treatmen that consists of supplying high concentrations of oxygen in a Hyperbaric Chamber pressurized to a mínimum pressure of 1.4 ATA (higher than the normal ambient atmospheric pressure, which is 1 atmosphere). This generates hyperoxia which has different physiological effects on the body.
Hyperbaric Treatment is indicated for non-healing wounds, radiation injuries, as well as different hypoxic or ischemic events (such as carbon monoxide toxicity, infections, etc.).
In recent years, different clinical trials have demonstrated the efficacy of HBOT for neurological pathologies including idiopathic sudden sensorineural hearing loss, stroke and post-traumatic brain injury, central sensitization syndrome such as fibromyalgia syndrome, age-related cognitive syndrome, and even Alzheimer's.
Hachmo Y, Hadanny A, Abu Hamed R, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial. Aging (Albany NY). 2020 Nov 18;12. doi: 10.18632/aging.202188. Epub ahead of print. PMID: 33206062.