Although the high pressure chambers are almost 200 years old and there are many protocols, the new medium pressure technology is so efficient and does not carry the explosive and safety hazards required by high pressure chambers. Both technologies have similar performance and even the dose of oxygen provided at medium pressure gives in some cases a greater anti-inflammatory effect than high pressure chambers.
All the hyperbaric chambers, high and low pressure, do the same job: they generate a HYPEROXIA. The hyperoxia is only a dose of O2 that dissolves in the plasma and depends on 5 variables that act pondering each other and can easily replace one another to obtain the dose of O2 needed:
- Oxygen: in both technologies it is 100%
- The pressure: in high pressure it is variable and in medium pressure it is fixed 1.45 ATM.
- The duration of the session: generally in half pressure we use 60 minutes with 3 minutes of compression and 2 minutes of decompression, obtaining 55 minutes of treatment per hour. At high pressure it takes 15 to 20 minutes of compression and decompression leaving only 20 to 30 minutes of treatment per hour.
- The number of sessions: it is indicated by the doctor.
- The weekly frequency of the sessions, also indicated.
The HBOT that uses medium pressure cameras is much safer than the one that works with cameras that perform the treatment at higher pressures. There are practically no reports of adverse events in patients of the BioBarica centers.
Working at 1.45 ATM is safer than working at 2.4 ATM in neurotoxicity, because neuronal excitability is dose-dependent oxygen. While at higher pressures a degree of neuronal hyper-excitability is obtained, when the patient breathes 100% oxygen at the pressure that the Revitalair chambers work, a state of neuronal sedation occurs. These results suggest that HBOT at medium pressure could be used in the treatment of patients with a history of seizures of other etiology and / or epileptic patients. This pressure is ideal for treatment in pediatric patients.
In recent years, treatments at pressures close to the minimum required pressure established by Hyperbaric Medicine Societies have been applied in several pathologies. Around 1.45 ATM is safer, easier to apply and shows excellent therapeutic efficacy.
The hyperbaria achieved by the cameras working at 1.45 atm produces a sufficiently high plasma hyperoxia (10 times more) and that greatly exceeds the minimum necessary oxygen pressure, calculated mathematically, at the level of the small blood vessels in all tissues.
In neurology, superior therapeutic effects were achieved by working with pressures less than 2 ATM than at higher pressures. The researchers suggest that the neuroplasticity and axonal regeneration is achieved with low-level oxygen doses, since at higher oxygen levels the reactive oxygen species are toxic for the neuron and the therapeutic effect is not reached.
Some researchers even reported that TOHB at 1.5 ATM is more effective in the anti-inflammatory, angioprotective, endothelial cell signaling, oxidative stress and cellular apoptosis than treatment at 2.4 ATM and propose the medium-pressure HBOT for the treatment of wounds instead of the use of HBOT at pressures> 2 ATM. In analogy with pharmacological therapies, HBOT should ensure that the level of O2 remains within the therapeutic window. That is, to exceed the minimum threshold necessary to fulfill the vital functions of aerobic cells, without exceeding the concentration ceiling, avoiding the toxicity associated with the excessive production of reactive O2 species (ERO).
An important item is to adjust the therapeutic dose of ROS in pediatric patients. The average pressure is currently used for the treatment of neurological pathologies and HBOT in pediatrics. This is achieved effectively using Revitalair technology cameras.
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