The Hyperoxia produces a significant increase in the amount of oxygen diluted in the blood plasma, favouring cellular metabolism and allowing oxygen to reach the brain, cartilages, bones and tissues that, due to diverse circulatory alterations, do not properly receive it. This hyperoxia produces a large chain of physiological effects in the body.
The increase of available O2 in small arteries and capillaries promote vasoconstriction, which occurs in healthy tissues without oxygen deterioration, promoting fluid redistribution flow to hypoperfused areas.
Angiogenesis and Neovascularization
The hyperoxia stimulates and promotes the formation of small vessels, thus improving perfusion.
Collagen synthesis stimulation
The hyperoxia induces the proline hydroxylation and fibroblast proliferation, promoting collagen synthesis, critical to the wound healing process and tissues rehabilitation.
Cellular immunity stimulation
The Polymorphonuclears is a type of white blood cell that uses free radicals as bactericidal mechanism. This process is favoured and stimulated by the presence of O2.
Oxidative Stress and Inflammatory Response Regulation
The hyperoxia acts on regulators and mediators of the inflammatory response and decreases the oxidative stress, resulting in anti-inflammatory effects and cellular damage decrease.
Stem Cells Stimulation
The hyperoxia stimulates the differentiation and liberation of Stem Cells, helping the tissue rehabilitation process and the formation of new blood vessels.
Cellular immune response to infections
In adverse conditions such as hypoxia, the predisposition to infections increases. In contrast, in hyperoxic conditions some cells of the immune system respond to the presence of pathogenic noxas, exerting their bactericidal action through the production of ROS, free radicals and peroxidase enzymes.
The hyperoxia stimulates the bone-forming cells differentiation, favouring osteogenesis and bone rehabilitation.
In addition to improving perfusion through the formation of new vessels and cerebral oxygenation, the hyperoxia increases neuroplasticity and stimulates peripheral axonal regeneration.
Increased success in flaps and implants
The hyperoxia increases the acceptance rate of implants and flaps used in burn and reconstructive surgeries.